Description
The SOX2 is a transcription factor, a member of the SRY-related HMG-box (SOX) family involved in the regulation of embryonic development and in the determination of cell fate. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. When SOX-2 is expressed in self-renewing progenitor cells, it acts to inhibit neuronal differentiation. Sox-2 is considered as an appropriate cell-specific marker in vivo dynamics of the neural progenitor cell compartment as well as in the adult brain